Fig. 6.

Increased glucose consumption by brains of neonatal SCOT-Neuron-KO mice. A: [1-¹³C]glucose labeling of lactate, a surrogate for glycolysis in brains of SCOT-Neuron-KO (on the flox/rec germline background) and control mice, 30 min after ip injection of [1-¹³C]glucose into P2 animals. B: ¹³C labeling of glutamate (surrogate for terminal oxidation in the tricarboxylic acid cycle) in these same cerebral extracts; n = 4/group. *P < 0.05 by Student's t-test. C: relative mRNA abundance of gluconeogenic [phosphoenolpyruvate carboxykinase (Pck1)] and ketogenic [hydroxymethylglutaryl-CoA synthase (Hmgcs2) and d-β-hydroxybutyrate-dehydrogenase (Bdh1)] genes in livers of P2 SCOT-Neuron-KO and control mice; n = 5/group.