Table 3.

Serum AcAc-to-d-βOHB ratios in adult mice

Oxct1 Genotype, condition	n	AcAc-to-d-βOHB Ratio
flox/flox, 48-h fast	12	0.30 ± 0.11
Heart-KO, 48-h fast	7	0.37 ± 0.12
Muscle-KO, 48-h fast	4	0.54 ± 0.14
flox/flox; Neuron-KO, 48-h fast	10	0.60 ± 0.13
flox/rec, 48-h fast	3	0.88 ± 0.33
flox/rec; Neuron-KO, 48-h fast	10	0.39 ± 0.07
+/+, 48-h fast	8	0.61 ± 0.17
+/−, 48-h fast	6	0.69 ± 0.18
+/+, 2-wk KD	9	0.17 ± 0.04
+/−, 2-wk KD	6	0.20 ± 0.03

n, No. of mice. AcAc, acetoacetate; d-βOHB, d-β-hydroxybutyrate; KO, knockout; KD, low-protein, very-low-carbohydrate, and high-fat ketogenic diet.