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Effect of SS31 in ameliorating burn injury-induced hypermetabolism (study 2). Indirect calorimetry was measured on post-burn day 7. Burn injury increased V̇o2, V̇co2, and EE. SS31 treatment significantly attenuated the hypermetabolic rate. Values are expressed as means ± SE; n = 7 in each group. *P < 0.001 vs. sham-saline group; †P = 0.001 vs. sham-saline group; ‡P < 0.001 vs. burn-saline group; §P = 0.001 vs. burn-saline group, two-factor factorial ANOVA.
