Nearest-neighbor CD distances for descending and ascending segments of a single loop of Henle, as they descend and ascend the corticopapillary axis. A: the AQP1-positive DTL lies distant from the CDs during the initial descent from 0 to ∼700 μm and thereafter approaches the CDs, the AQP1-negative DTL begins contacting CDs toward its terminus (below ∼1,700 μm), and the prebend lies close to or in contact with CDs for most of its descent. B: the ATL makes contact with CDs for most of its ascent between 1,000 and 2,500 μm but moves away from CDs as it nears the OM-IM boundary.