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. 2012 Oct 24;304(3):F289–F299. doi: 10.1152/ajprenal.00517.2012

Fig. 2.

Fig. 2.

A: effects of immune tolerance to HSP70 in renal IL-6 (left panel) and IL-10 (right panel) expression. Data obtained from 5 rats of each group. Renal abundance of IL-6 is increased in the SSHTN group and suppressed in the group tolerized with the HSP70 peptide (tolerized) that showed overabundance of IL-10. Vehicle-treated rats had IL-6, IL-10, CTLA-4 mRNA (n = 5, not shown) similar to those in the untreated control group. Data shown in the columns are corrected for the β-actin expression used as internal control. Solid columns, SSHTN; hatched columns, tolerized; open columns, control. *P < 0.05, **P < 0.001, ***P < 0.001. B: lymphocyte (CD5+ cells) and macrophage (CD68-positive cells) accumulation in tubulointerstitial areas of the kidney was increased in rats with SSHTN and suppressed by tolerization. Each symbol corresponds to one rat. *P < 0.05, **P < 0.001, ***P < 0.001. Original magnification of the microphotographs, ×400.