Table 2.

Agreement between symptoms in first and third, and second and third, major depressive episodes during prospective follow-up

Symptom	Symptom prevalence			Agreement (Episode 1 versus 3)					Agreement (Episode 2 versus 3)
	Episode 1	Episode 2	Episode 3	Observed	Expected	kappa	z	p	Observed	Expected	kappa	z	p
Hypersomnia	30.9	36.9	39.6	66.9	56.2	0.246	3.033	0.0012	67.8	55.1	0.282	3.503	0.0002
Poor concentration	67.1	69.1	71.8	77.5	71.1	0.223	2.732	0.0032	75.7	71.4	0.150	1.841	0.0328
Worthlessness	73.8	75.0	76.5	79.9	75.4	0.184	2.241	0.0125	76.5	73.3	0.121	1.483	0.0691
Insomnia	34.7	34.5	32.4	64.6	56.8	0.179	2.168	0.0151	64.2	57.2	0.165	1.994	0.0231
Psychomotor agitation	16.8	20.1	17.4	74.3	69.3	0.163	1.992	0.0232	78	70.5	0.255	3.116	0.0009
Guilt/rumination	37.6	37.6	42.3	65.1	58.7	0.155	1.892	0.0293	66.9	57.6	0.221	2.707	0.0034
Suicidal ideation	21.5	26.2	19.5	71.1	66.3	0.142	1.743	0.0406	76.2	69.6	0.217	2.656	0.0040
Poor energy	87.9	81.9	81.2	85.6	83.3	0.134	1.715	0.0432	83.6	83.7	-0.007	-0.086	0.5343
Hyperphagia	19.5	20.8	19.5	70.3	67.5	0.086	1.051	0.1466	76.8	68.2	0.271	3.307	0.0005
Psychomotor retardation	37.6	38.9	37.6	61.4	58.0	0.081	0.986	0.1621	60.4	57.6	0.066	0.801	0.2115
Depressed mood	77.2	63.8	70.5	61.9	60.6	0.034	0.458	0.3235	75.8	66.5	0.279	3.497	0.0002
Loss of appetite	26.8	26.8	31.5	61.9	62.0	-0.004	-0.043	0.5174	70.1	60.4	0.246	3.012	0.0013
Loss of interest	90.6	85.8	89.3	85.5	86.0	-0.039	-0.496	0.6901	91.1	91.3	-0.021	-0.261	0.6030
Distractibility	29.5	42.3	34.2	65.8	57.5	0.195	2.480	0.0066	66.3	60.3	0.151	1.866	0.0310
Flight of ideas	8.1	14.8	10.1	78.7	76.4	0.098	1.251	0.1054	83.4	80	0.171	2.095	0.0181
Goal-directed activity	2.0	2.7	0.7	94.5	94.1	0.063	0.775	0.2192	95.1	95.4	-0.054	-0.665	0.7471
Decreased need for sleep	0.7	2.0	2.7	96.3	96.4	-0.025	-0.345	0.6349	95.5	95.6	-0.027	-0.394	0.6531
Talkativeness	3.4	2.0	1.3	91.1	91.4	-0.032	-0.390	0.6517	94.6	92.8	0.252	3.246	0.0006
High-risk behavior	1.3	4.0	2.0	93.6	93.9	-0.039	-0.522	0.6990	95.3	94.9	0.085	1.096	0.1365
Hallucinations	2.7	1.3	1.3	96.0	96.0	-0.018	-0.236	0.5935	96.0	96.0	-0.018	-0.236	0.5935
Delusions	2.0	1.3	2.0	96.6	96.7	-0.016	-0.204	0.5809	97.3	96.1	0.320	3.902	0.0001
Psychosis	4.0	2.7	3.4	93.3	93.5	-0.033	-0.415	0.6610	94.0	92.9	0.151	1.848	0.0323
	Mean (SD)	Mean (SD)	Mean (SD)				r	p				r	p
% Days anxious	45.4 (43.2)	51.5 (43.7)	47.4 (42.8)				0.31	0.0001				0.29	0.0004
% Days irritable	34.3 (38.9)	34.5 (38.9)	31.5 (36.2)				0.20	0.0164				0.34	< 0.0001
CGI	4.05 (0.88)	4.06 (0.73)	3.97 (0.74)				0.11	0.1907				0.14	0.0869
Manic symptoms	0.85 (0.99)	0.70 (0.88)	0.59 (0.81)				0.01	0.8920				0.15	0.0700
Depressive symptoms	5.91 (1.24)	5.93 (1.18)	5.91 (1.04)				-0.03	0.6905				0.01	0.8920

Shaded rows indicate symptoms with nominally significant (p < 0.05) association between first and third episodes and second and third episodes.