. 2013 Feb 7;3:1225. doi: 10.1038/srep01225

Table 1. Detailed list of human angiogenin mutations reported in ALS patients with their corresponding loss-of-functions data from reported experiments and our MD simulations.

Human ANG mutation	Experimental findings from literatures		MD simulation results		Remarks	Reference
	Ribonucleolytic activity	Nuclear translocation activity	Ribonucleolytic activity	Nuclear translocation activity
K17I^#	Loss⁸,¹⁰,¹¹	No loss⁸,¹¹	Loss⁷	No loss⁷		31,32,33,34,35
S28N^#	Loss⁸,¹¹	Loss⁸,¹¹	Loss⁷	Loss⁷		8
P112L^#	Partial loss⁸,¹¹	Loss⁸,¹¹	Partial loss⁷	Loss⁷		8
I46V	Partial loss¹⁰,¹¹	No loss¹¹	Partial loss	No loss		31, 32, 35, 36, 37, 38, 39
K17E	Partial loss¹⁰,¹¹	No loss¹¹	Partial loss	No loss		31
R31K	Minor loss¹⁰,¹¹	No loss¹⁰,¹¹	Minor loss	No loss		31
V103I	Not reported	Not reported	No loss	Loss		40
D22G	Not reported	Not reported	Loss	No loss		41
V113I^#	Minor loss¹¹	Transient activity¹¹	No loss⁷	Loss⁷		37
Q12L*	Loss¹⁰,¹¹	No loss¹¹			*Located near His13	31
C39W*	Loss¹⁰,¹¹	Not reported			*Located near Lys40	31
K40I*	Loss¹⁰,¹¹	No loss¹¹			*Mutation of Lys40	31, 5
H114R*	Loss¹¹	No loss¹¹	*MD simulations not performed		*Mutation of His114	37
F-13S*	Not reported	Not reported			*Not located in mature ANG	37, 38
F-13L*	Not reported	Not reported			*Not located in mature ANG	35
M-24I*	Not reported	Not reported			*Not located in mature ANG	37, 38
P-4S*	Not reported	Not reported			*Not located in mature ANG	37, 8
R121C	Not reported	Not reported	No loss	No loss	SOD1-G93D patient with R121C-ANG mutation	23
R121H	No loss¹¹	Transient activity¹¹	No loss	Loss		36
K54E	No loss¹¹	Not reported	No loss	Loss		35
T80S	Not reported	Not reported	Loss	No loss		32, 44
F100I	Not reported	Not reported	No loss	Loss		32, 44
N49S	Not reported	Not reported	Minor loss	No loss		42
L35P^#	Not reported	Not reported	Loss⁷	Loss⁷		43
K60E^#	Not reported	Not reported	No loss⁷	No loss⁷		43

^#ANG mutants for which simulation results are presented in reference 7.