Table 2.
Prevalence of HHV-6-DNA (copies/mL) and HHV-6-antibodies (U/mL) among different subtypes of MS. HHV-6-DNA was analyzed in serum via qPCR as described previously. Concentration of plasma anti-HHV-6, IgG and IgM were measurement in an automated instrument, according to the manufacturer's instructions. Data are representative of three independent experiments.
| Saliva | Serum | PBMCs | CSF | Anti-IgG | Anti-IgM | |
|---|---|---|---|---|---|---|
| P (%) | ||||||
| [mean ± SD] | ||||||
| MS (n = 78) | ||||||
| (1) RRMS (n = 46) CSF (n = 22) |
6 (13.04) [127 ± 12.43] |
35 (76.08) [272 ± 39.15] |
36 (78.26) [178 ± 42.60] |
10 (45.45) [128 ± 7.58] |
38 (82.60) [15.96 ± 1.43] |
22 (47.82) [24.85 ± 1.92] |
| (2) SPMS (n = 11) CSF (n = 6) |
3 (27.27) [128 ± 9.84] |
7 (63.63) [294 ± 44.77] |
7 (63.63) [151 ± 14.44] |
1 (16.66) [145] |
11 (100) [16.51 ± 2.27] |
4 (36.36) [25.67 ± 1.43] |
| (3) PPMS (n = 21) CSF (n = 10) |
0 (—) [—] |
5 (23.80) [165 ± 12.45] |
9 (42.85) [125 ± 7.23] |
0 (—) [—] |
12 (57.14) [13.32 ± 1.17] |
1 (4.76) [23.05] |
|
| ||||||
| Sig. (2-tailed) | ||||||
| Subtypes (1), (2) | NS | NS | P < 0.05 | NS | NS | NS |
| Subtypes (1), (3) | — | P < 0.001 | P < 0.001 | — | P < 0.001 | NS |
| Subtypes (2), (3) | — | P < 0.001 | P < 0.001 | — | P < 0.001 | NS |
PBMCs: peripheral blood mononuclear cells; CSF: cerebrospinal fluid; PPMS: primary progressive MS; RRMS: relapsing-remitting MS; SPMS: secondary progressive MS; P: positive; NS: not significant.