Figure 1.

Schematic structures of Gab family docking proteins. Shown are the schematic domain structures of three human Gab proteins (Gab1–3), the putative human Gab4 protein, Drosophila DOS, and C. elegans SOC-1. All Gab proteins consist of a highly conserved N-terminal PH domain that is involved in membrane targeting. The central proline-rich regions mediate the association with SH3 domain-containing adaptor proteins such as Grb2. Consensus binding motifs favored by various SH2 domain-containing proteins such as SHP2, p85, Crk, and PLCγ are indicated.