Table 2. CD4+ T-cell response the day before the i.n. challenge with C. trachomatis MoPna.
Vaccine | CD4+ T-cell proliferative response (× 103 cpm) to |
|
---|---|---|
EB | Medium | |
nMOMP + CTB-CpG | 5.3 ± 0.01b, c | 0.3 ± 0.05 |
nMOMP + CT + CpG ODN | 3.9 ± 0.8d | 0.3 ± 0.1 |
Ovalbumin + CTB-CpG | 1.6 ± 0.5 | 0.5 ± 0.16 |
Ovalbumin + CT + CpG ODN | 2.5 ± 1.1 | 0.5 ± 0.2 |
C. trachomatis | 21.4 ± 3.0 | 0.2 ± 0.02 |
The values are means ± SE for triplicate cultures. The data are from one of the experiments representative of duplicate experiments. UV-inactivated C. trachomatis MoPn EB were added at a ratio of EB to T cells of 1:5.
p < 0.05 as determined by the Student t test for the comparison with the group immunized with nMOMP + CT + CpG ODN
p < 0.001 as determined by the Student t test for the comparison with the group immunized with ovalbumin + CTB-CpG
p > 0.05 as determined by the Student t test for the comparison with the group immunized with ovalbumin with adjuvant of CT + CpG ODN