Table 1.

PK parameters for maraviroc concentrations measured in macaque vaginal fluid and plasma following vaginal administration of the various maraviroc HEC gels.

Maraviroc gel conc. / dose (% w/w / total dose)	Vaginal fluid			Plasma
	Cmax (ng/mL)	Tmax (h)	AUC (ng·h/mL)	Cmax (ng/mL)	Tmax (h)	AUC (ng·h/mL)
0.003 / 0.12 mg	18 960	12	314 400	0.16	2	0.658
0.01 / 0.4 mg	149 700	0.5	583 800	0.32	2	3.774
0.03 / 1.2 mg	122 300	0.5	833 500	1.32	0.5	8.371
0.10 / 4.0 mg	394 400	2	2 420 000	3.33	0.5	41.12
0.30 / 12 mg	1 387 000	0.5	5 351 000	18.18	2	60.40
3.3 / 132 mg	6 564 000	0.5	57 450 000	147.9	2	626.5