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. 2012 Dec 10;19(5-6):657–668. doi: 10.1089/ten.tea.2012.0053

FIG. 2.

FIG. 2.

Otoscopic observation of tympanic membrane (TM) healing after grafting. The lateral aspect of TMs was observed with otoscopy. The transparency of SFS (fully transparent) and ACS (semi-transparent) allowed direct observation of the TM healing, whereas the opacity of paper patch and Gelfoam resulted in difficulty with examination. SFS and ACS adhered well to the TM remnant throughout the healing process; however, paper patch and Gelfoam partially detached at 7 days. Microvessels were most prominent in the control group (3–14 days) compared with scaffold-treated TMs. Perforation closure of SFS and ACS was observed at 7 days compared with 9 days in the paper and Gelfoam groups and 14 days in the control group. Scar formation was visible at 28 days in the paper patch, Gelfoam, and control groups (white arrowheads). White arrows indicate scaffolds; asterisk indicates perforation.