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. 2013 Jan 15;3(1):e212. doi: 10.1038/tp.2012.136

Figure 1.

Figure 1

Mice expressing a dominant negative-SNARE protein in astrocytes do not demonstrate beneficial effects of sleep deprivation on depressive-like behaviors. (a) Schematic diagram of tTA and tetO-driven expression of EGFP and dnSNARE. (b) Confocal images of EGFP expression in the frontal cortex of dnSNARE mice both off (left) and on (right) Dox. Quantification of EGFP intensity in frontal cortex (c) and hippocampal dentate gyrus (d). (e) Heat maps of wild-type and dnSNARE (± sleep deprivation) behavior in the last 4 min of the forced-swim task. (f) Time spent immobile in the last 4 min of the forced-swim task. (g) dnSNARE expression prevents sleep deprivation modulating immobile time in the tail-suspension test. (h) dnSNARE does not impair the ability of chronic (12 day) imiprimine from reducing immobility. ***P⩽0.001.