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. 2013 Jan 15;3(1):e207. doi: 10.1038/tp.2012.140

Figure 3.

Figure 3

Percentage of methylation (mean of brain-derived neurotrophic factor (BDNF) CpG exon IV and BDNF CpG exon I regions) according to depression severity (a), hopelessness (b) and impulsivity (c). The right panels in (a–c) indicate treatment response and percentage of methylation according to treatment response: for depression and hopelessness: A, ≤25% improvement; B, >25% to ≤50% improvement; C, >50% to ≤75% improvement; D, >75% improvement; and for impulsivity: a, 0% improvement; b, >0% to ≤10% improvement; c, >10% to ≤20% improvement; d, >20% improvement (gray bars indicate borderline personality disorder (BPD) at baseline and black bars indicate BPD after treatment). Bars represent s.d. *P<0.05; **P<0.01; ***P<0.001. The left panels in (a–c) indicate scatter plots of percentage of methylation and severity of depression, hopelessness and impulsivity. BPD T0, borderline personality disorder subjects at baseline; BPD T4, borderline personality disorder subjects after treatment; non-RES, nonresponders (≤50% improvement); RES, responders (>50% improvement).