Table 2. Percentage of methylation (mean of BDNF CpG exon I and BDNF CpG exon IV regions) before and after I-DBT according to treatment response.
| Mean (baseline) | s.d. | Mean (end) | s.d. | N | β | P-value | 95% CI | ||
|---|---|---|---|---|---|---|---|---|---|
| BDI | |||||||||
| ≤25% | 32.77 | 13.67 | 30.63 | 10.64 | 29 | 1.43 | 4.07 × 10–13 | 1.04 | 1.81 |
| >25 to ≤50% | 37.67 | 10.27 | 24.24 | 7.29 | 21 | 0.51 | 0.01 | 0.15 | 0.87 |
| >50 to ≤75% | 35.68 | 7.50 | 13.59 | 4.38 | 22 | −0.36 | 0.06 | −0.74 | 0.02 |
| >75% | 32.27 | 8.99 | 4.73 | 3.17 | 15 | −0.67 | 0.01 | −1.18 | −0.16 |
| Hopelessness | |||||||||
| ≤25% | 11.49 | 4.71 | 7.98 | 5.04 | 40 | 0.87 | 0.00 | 0.48 | 1.27 |
| >25 to ≤50% | 11.05 | 4.84 | 4.42 | 2.87 | 14 | 0.63 | 0.01 | 0.14 | 1.11 |
| >50 to ≤75% | 11.11 | 4.73 | 3.46 | 2.13 | 21 | −0.38 | 0.14 | −0.88 | 0.13 |
| >75% | 10.70 | 4.86 | 1.57 | 0.89 | 9 | −0.36 | 0.20 | −0.92 | 0.19 |
| BIS-10 | |||||||||
| 0 | 64.06 | 17.52 | 71.26 | 16.37 | 36 | 0.85 | 0.0004 | 0.38 | 1.31 |
| >0 to ≤10% | 71.54 | 19.27 | 68.21 | 18.32 | 18 | 0.52 | 0.04 | 0.03 | 1.01 |
| >10 to ≤20% | 74.69 | 18.20 | 64.48 | 15.56 | 13 | −0.32 | 0.19 | −0.81 | 0.16 |
| >20% | 70.07 | 14.01 | 50.94 | 11.36 | 16 | −0.36 | 0.14 | −0.83 | 0.12 |
Abbreviations: BDI, Beck Depression Inventory; BDNF, brain-derived neurotrophic factor; BIS-10, Barrat Impulsiveness Scale; CI, confidence interval; I-DBT, intensive dialectical behavior therapy.