Table 2. Pathway enrichment analysis of the effect of sertraline exposure from baseline to week 4.
| Pathway name | PT | OV | Metabolites | P | Q |
|---|---|---|---|---|---|
| Transmembrane transport of small molecules | R | 9 | 170 (192) | 1.21E−06 | 1.51E−03 |
| Signaling by GPCR | R | 7 | 84 (93) | 1.30E−06 | 1.51E−03 |
| Signal transduction | R | 7 | 89 (98) | 1.93E−06 | 1.51E−03 |
| Regulation of lipid metabolism by PPAR-α | R | 3 | 5 (5) | 3.60E−06 | 2.12E−03 |
| SLC-mediated transmembrane transport | R | 8 | 147 (165) | 4.85E−06 | 2.28E−03 |
| Free fatty acid receptors | R | 4 | 19 (23) | 8.34E−06 | 3.27E−03 |
| Transport of fatty acids | R | 3 | 9 (9) | 2.97E−05 | 9.96E−03 |
| GPCR ligand binding | R | 5 | 66 (75) | 9.26E−05 | 0.027 |
| Gα (q) signaling events | R | 4 | 38 (43) | 1.45E−04 | 0.038 |
| Nucleotide metabolism | W | 3 | 16 (17) | 1.91E−04 | 0.045 |
| Fatty acid, triacylglycerol and ketone body metabolism | R | 5 | 83 (89) | 2.78E−04 | 0.059 |
| Glucose homeostasis | W | 3 | 21 (21) | 4.44E−04 | 0.087 |
| Arachidonate production from DAG | R | 2 | 5 (5) | 5.32E−04 | 0.096 |
| Class A/1 (Rhodopsin-like receptors) | R | 4 | 56 (64) | 6.62E−04 | 0.111 |
Abbreviations: PCR, principal component regression; PT, source of pathway; R, Reactome; W, Wikipathways; OV, number of overlapping metabolites; P, P-value calculated for metabolites; Q, Q-value calculated for metabolites after correction for FDR.