Figure 4.

Enzymatic degradation of vHipp perineuronal nets results in an enhanced locomotor response to amphetamine. vHipp chondroitinase ABC treatment did not appear to alter spontaneous locomotor activity in a novel environment; however, a significant increase in the locomotor response to amphetamine (administered at the dashed line) was observed in rats with perineuronal net degradation. ^†represents a mean effect of treatment, whereas *indicates significant difference between chondroitinase ABC and penicillinase in pairwise multiple comparisons across time; Two-way ANOVA, followed by Holm–Sidak post-hoc, n=16–18 rats per group).