Scheme 2.
Synthesis of 7–9. Conditions: (i) HCl·H2NOMe, pyridine, rt, 12 h; (ii) EDC, NHS, dioxane, rt, 3 h; (iii) 6, Et3N, dioxane/MeOH, rt; (iv) HCl·H2NOH, pyridine, rt, 12 h; (v) DCC, NOHP, 6, Et3N, dioxane, rt, 24 h.
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