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. 2012 Jan 4;32(1):229–242. doi: 10.1523/JNEUROSCI.1233-11.2012

Figure 7.

Figure 7.

Impairment of mitochondrial bioenergetics in mutant SOD1 motor neuron axons. A, Average TMRM fluorescence intensity (mitochondrial membrane potential) of all mitochondria in proximal and distal segments of non-transgenic and G93A SOD1 motor neurons (8 div). n (mitochondria) = 285 control and 207 G93A. B, Representative kymographs of TMRM-labeled mitochondria from distal axonal segments of control and mutant SOD1 motor neurons, used to correlate membrane potential and mitochondrial transport. Scale bars, 10 μm (horizontal), and 1 min (vertical). C, TMRM intensity measured as the integrated fluorescence in each mitochondrion/area in pixels and expressed as a proportion of average potential in all mitochondria. n (axons) = 12 control and 10 G93A. Data from 3 independent motor neuron isolations. The error bars represent ± SE. *p < 0.05.