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. 2012 Jan 4;32(1):372–380. doi: 10.1523/JNEUROSCI.3222-11.2012

Figure 7.

Figure 7.

NMDA receptor–calpain–calcineurin signaling contributes to increased GluR2-lacking AMPAR activity of spinally projecting PVN neurons in SHR. A, I–V curves and original current traces (inset) of AMPAR-EPSCs in labeled PVN neurons of SHR treated with AP-5 (50 μm, n = 8) or vehicle (n = 10). B, I–V curves and original recordings (inset) of AMPAR-EPSCs in the PVN neurons of SHR treated with FK506 (1 μm, n = 9) or vehicle (n = 7). C, I–V curves and representative traces (inset) of AMPAR-EPSCs in PVN neurons of SHR treated with calpeptin (100 μm, n = 9) or vehicle (n = 8). HP, Holding potentials. D, Summary data show effects of treatment with AP-5 (n = 8), FK506 (n = 9), or calpeptin (n = 9) on the RI of AMPAR-EPSCs of labeled PVN neurons in SHR. Data are presented as mean ± SEM. *p < 0.05 compared with the vehicle control group.