Figure 1.

Immunostaining of REG Iα in biopsy samples obtained from gastric cancer tissues. The biopsy samples were obtained before chemotherapy (A, B, and D) and after disease progression (C). (A) The REG Iα-negative gastric cancer (diffuse type). (B) The REG Iα-positive gastric cancer (intestinal type). (C) The REG Iα-positive gastric cancer (diffuse type). This sample was obtained from the same patient as that in (A) when he developed disease progression after S-1/CDDP treatment. (D) The REG Iα-positive signet-ring cell carcinoma (diffuse type).