Table 3. Predictors of mastectomy after neoadjuvant chemotherapy.
|
Univariate analysis |
Multivariate analysis |
|||||
|---|---|---|---|---|---|---|
| Factor | ORa | 95% CI | P-value | ORa | 95% CI | P-value |
| Age (years) |
0.99 |
0.98–1.00 |
0.02 |
0.99 |
0.98–1.00 |
0.02 |
| Multifocal tumour |
|
|
<0.001 |
|
|
|
| No | 1.00 | — | — | 1.00 | — | — |
| Yes |
4.6 |
3.28–6.46 |
|
3.85 |
2.70–5.48 |
<0.001 |
| Tumour size (cm) |
1.42 |
1.33–1.51 |
<0.001 |
1.30 |
1.21–1.40 |
<0.001 |
|
N stage | ||||||
| N0 | 1.00 | — | — | 1.00 | — | — |
| N1 or sup |
2.03 |
1.66–2.48 |
<0.001 |
1.39 |
1.09–1.77 |
0.007 |
|
AJCC stage | ||||||
| I/II | 1.00 | — | — | 1.00 | — | — |
| III/IV |
3.51 |
2.78–4.41 |
<0.001 |
1.89 |
1.41–2.54 |
<0.001 |
|
Nuclear grade | ||||||
| I | 1.00 | — | — | 1.00 | — | — |
| II | 0.81 | 0.47–1.37 | 0.43 | 1.43 | 0.75–2.69 | 0.27 |
| III |
0.51 |
0.35–1.00 |
0.05 |
0.85 |
0.44–1.62 |
0.61 |
|
Histological subtype | ||||||
| IDC | 1.00 | — | — | 1.00 | — | — |
| ILC | 2.25 | 1.52–3.33 | <0.001 | 1.86 | 1.15–2.99 | 0.01 |
Abbreviations: AJCC=American Joint Committee on Cancer; CI=confidence interval; IDC=invasive ductal carcinoma; ILC=invasive lobular carcinoma; OR=odds ratio.
a
OR=1 is the reference; OR<1, factor associated with lower mastectomy rate; OR>1, factor associated with higher mastectomy rate.