Table 3. Adjusted associationsa between ESR, ALP, anaemia, and survival outcomes, stratified by stages.
| Variable | pT1-2 | pT3-4 | P for interaction | ||
|---|---|---|---|---|---|
|
No. of deathb | |||||
| Overall survival | 97 | 68 | — | ||
| Cancer-specific survival |
74 |
61 |
— |
||
| |
Low |
High |
Low |
High |
|
|
High ESRc | |||||
| Overall survival | 1.00 (Ref) | 1.39 (0.75–2.57) | 1.00 (Ref) | 1.19 (0.32–4.38) | 0.209 |
| Cancer-specific survival |
1.00 (Ref) |
2.30 (1.07–4.93) |
1.00 (Ref) |
1.12 (0.25–5.04) |
0.027 |
|
High ALPc | |||||
| Overall survival | 1.00 (Ref) | 1.67 (0.65–4.26) | 1.00 (Ref) | 0.50 (0.12–2.04) | 0.028 |
| Cancer-specific survival |
1.00 (Ref) |
1.28 (0.43–3.82) |
1.00 (Ref) |
0.67 (0.14–3.05) |
0.076 |
| |
High |
Low |
High |
Low |
|
|
Anaemia (Hb)d | |||||
| Overall survival | 1.00 (Ref) | 2.62 (1.38–4.97) | 1.00 (Ref) | 1.72 (0.39–7.64) | 0.281 |
| Cancer-specific survival |
1.00 (Ref) |
2.68 (1.14–6.26) |
1.00 (Ref) |
1.13 (0.21–6.15) |
0.141 |
|
Anaemia (Hct)d | |||||
| Overall survival | 1.00 (Ref) | 2.31 (1.29–4.13) | 1.00 (Ref) | 1.24 (0.31–5.01) | 0.210 |
| Cancer-specific survival | 1.00 (Ref) | 1.57 (0.71–3.45) | 1.00 (Ref) | 1.04 (0.23–4.76) | 0.191 |
Abbreviations: ESR=erythrocyte sedimentation rate; ALP=alkaline phosphatase; Hct=haematocrit; Hb=haemoglobin; Ref=reference.
For ESR, the model was adjusted for levels of ALP and Hb in addition to covariates listed in the Model 2 (except for tumour stage and surgical types); For ALP, the model was adjusted for levels of ESR and Hb in addition to covariates listed in the Model 2 (except for tumour stage and surgical types); For Hb, the model was adjusted for levels of ESR and ALP in addition to covariates listed in the Model 2 (except for tumour stage and surgical types); For Hct, the model was adjusted for ESR and ALP in addition to covariates listed in the Model 2 (except for tumour stage and surgical types).
For ESR variable, total no. of deaths from any cause were 87 for pT1-2 and 59 for pT3-4; total no. of deaths from RCC were 67 for pT1-2 and 52 for pT3-4; for others, total no. of deaths were same as above.
The following cutoff points were chosen to identify high levels (abnormal laboratory values): ESR >22 mm per hour for males, >29 mm per hour for females; ALP >115 U l−1 for both males and females.
The following cutoff points were chosen to identify low levels (abnormal laboratory values): Hb <13.5 g dl−1 for males, <12 g dl−1 for females; Hct <41% for males, <36% for females.