Table 4. Adjusted associationsa between ESR, ALP, anaemia, and survival outcomes, stratified by BMI.
| Variable | BMI <25 kg m−2 | BMI ⩾25 kg m−2 | P for interaction | ||
|---|---|---|---|---|---|
|
No. of deathb | |||||
| Overall survival | 119 | 46 | — | ||
| Cancer-specific survival |
99 |
36 |
— |
||
| |
Low |
High |
Low |
High |
|
|
High ESRc | |||||
| Overall survival | 1.00 (Ref) | 1.90 (0.97–3.72) | 1.00 (Ref) | 1.09 (0.41–2.87) | 0.037 |
| Cancer-specific survival |
1.00 (Ref) |
3.53 (1.51–8.23) |
1.00 (Ref) |
1.84 (0.56–6.01) |
0.028 |
|
High ALPc | |||||
| Overall survival | 1.00 (Ref) | 0.97 (0.44–2.12) | 1.00 (Ref) | 1.35 (0.28–6.47) | 0.433 |
| Cancer-specific survival |
1.00 (Ref) |
0.64 (0.26–1.56) |
1.00 (Ref) |
3.04 (0.51–18.27) |
0.210 |
| |
High |
Low |
High |
Low |
|
|
Anaemia (Hb)d | |||||
| Overall survival | 1.00 (Ref) | 2.22 (1.12–4.40) | 1.00 (Ref) | 1.35 (0.47–3.87) | 0.097 |
| Cancer-specific survival |
1.00 (Ref) |
2.09 (0.90–4.85) |
1.00 (Ref) |
0.45 (0.10–2.05) |
0.046 |
|
Anaemia (Hct)d | |||||
| Overall survival | 1.00 (Ref) | 2.19 (1.09–4.38) | 1.00 (Ref) | 1.49 (0.58–3.87) | 0.071 |
| Cancer-specific survival | 1.00 (Ref) | 1.26 (0.55–2.89) | 1.00 (Ref) | 0.27 (0.05–1.47) | 0.023 |
Abbreviations: BMI=body mass index; ESR=erythrocyte sedimentation rate; ALP=alkaline phosphatase; Hct=haematocrit; Hb=haemoglobin; Ref=reference.
For ESR, the model was adjusted for levels of ALP and Hb in addition to covariates listed in the Model 2 (except for BMI); For ALP, the model was adjusted for levels of ESR and Hb in addition to covariates listed in the Model 2 (except for BMI); For Hb, the model was adjusted for levels of ESR and ALP in addition to covariates listed in the Model 2 (except for BMI); For Hct, the model was adjusted for ESR and ALP in addition to covariates listed in the Model 2 (except for BMI).
For ESR variable, total no. of deaths from any cause were 102 for BMI<25 kg m−2 and 44 for BMI⩾25 kg m−2; total no. of deaths from RCC were 85 for BMI<25 kg m−2 and 34 for BMI≥25 kg m−2; for others, total no. of deaths were same as above.
The following cutoff points were chosen to identify high levels (abnormal laboratory values): ESR >22 mm per hour for males, >29 mm per hour for females; ALP >115 U l−1 for both males and females.
The following cutoff points were chosen to identify low levels (abnormal laboratory values): Hb <13.5 g dl−1 for males, <12 g dl−1 for females; Hct <41% for males, <36% for females.