Figure 1.

The expression of hypoxia inducible factor 1α (Hif-1α), carbonic anhydrase IX (CaIX), vascular endothelial growth factor A (VEGF-A), mammalian target of rapamycin (mTOR) and AKT in benign, metastatic phaeochromocytomas (PCC)/paragangliomas (PGL) and normal adrenal medulla controls by immunohistochemistry. Immunohistoscore (IHS) values are presented as medians±interquartile ranges. An asterisk marks a statistically significant difference in median IHS values across indicated columns, whereas double asterisks mark a statistically significant difference in median IHS values between normal controls and tumour samples for each biomarker.