Table 2. Cox regression analyses for RP cohort (recurrence-free survival).

RP cohort (n=267)	Univariate		Multivariate (global model)		Multivariate (final model)
Variable (characteristics)	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value
Age at diagnosis (⩽62 vs >62 years)	1.05 (0.73–1.50)	0.80	—	—	—	—
Preoperative PSA (continuous)	1.05 (1.04–1.07)	<0.001	1.04 (1.03–1.06)	<0.001	1.04 (1.03–1.06)	<0.001
Gleason score (5–6 vs 7-10)	2.81 (1.83–4.31)	<0.001	1.60 (0.99–2.60)	0.056	1.72 (1.08–2.75)	0.023
Tumour stage (pT2 vs pT3)	3.35 (2.30–4.88)	<0.001	1.54 (0.88–2.69)	0.13	—	—
Nodal status (pN0 vs pN1)	3.36 (1.56–7.24)	0.002	1.68 (0.71–3.98)	0.24	—	—
Surgical margins (neg vs pos)	3.05 (2.11–4.41)	<0.001	1.77 (1.03–3.04)	0.038	2.38 (1.61–3.52)	<0.001
VEGF (low vs high)	2.84 (1.97–4.11)	<0.001	2.12 (1.41–3.20)	<0.001	2.05 (1.38–3.06)	<0.001
APN IHC (neg vs pos)	0.55 (0.37–0.80)	0.002	0.64 (0.42–0.98)	0.039	0.54 (0.36–0.80)	0.017

Abbreviations: APN=aminopeptidase N; CI=confidence interval; HR=hazard ratio; IHC=immunohistochemistry; PSA=prostate-specific antigen; RP=radical prostatectomy; VEGF=vascular endothelial growth factor.