Table 3. Cox regression analyses for CT cohort (cancer-specific survival).

CT cohort (n=111)	Univariate		Multivariate (global model)		Multivariate (final model)
Variable (characteristics)	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value
Age at diagnosis (⩽74 vs >74 years)	0.94 (0.53–1.68)	0.84	—	—	—	—
Gleason score (5–6 vs 7–10)	4.08 (1.72–9.69)	0.001	3.16 (1.08–9.27)	0.036	3.48 (1.20–10.1)	0.021
Endocrine treatment (yes/no)	0.97 (0.54–1.75)	0.93	—	—	—	—
Microvessel density (continuous)	1.09 (1.05–1.14)	<0.001	1.08 (1.02–1.13)	0.005	1.09 (1.03–1.14)	0.001
VEGF (low vs high)	2.34 (1.28–4.27)	0.006	1.61 (0.76–3.43)	0.213	—	—
APN IHC (neg vs pos)	0.17 (0.04–0.72)	0.017	0.27 (0.06–1.19)	0.084	0.23 (0.06–1.00)	0.049

Abbreviations: APN=aminopeptidase N; CI=confidence interval; CT=conservative treatment; HR=hazard ratio; IHC=immunohistochemistry; VEGF=vascular endothelial growth factor.