Table 3. Methylation markers differential between patients with and without extracapsular spread (ECS).
| Gene | Loci of methylation | Strand | Δβ | P -value (FDR) |
|---|---|---|---|---|
|
ADCYAP1
|
P398 |
F |
0.28 |
0.008 |
|
CALCA
|
E174 |
R |
0.33 |
0.016 |
|
CHGA
|
E52 |
F |
0.24 |
0.025 |
|
DBC1
|
E204 |
F |
0.21 |
0.021 |
|
DCC
|
P471 |
R |
0.34 |
0.008 |
|
DLK1
|
E227 |
R |
0.34 |
0.023 |
|
HTR1B
|
P222 |
F |
0.31 |
0.001 |
|
KDR
|
P445 |
R |
0.29 |
0.042 |
|
MOS
|
E60 |
R |
0.31 |
0.005 |
|
MT1A
|
P49 |
R |
0.30 |
0.003 |
|
NTRK3
|
E131 |
F |
0.21 |
0.039 |
|
PENK
|
E26 |
F |
0.21 |
0.011 |
|
SOX17
|
P287 |
R |
0.29 |
0.003 |
|
WT1
|
E32 |
F |
0.38 |
0.010 |
| WT1 | P853 | F | 0.24 | 0.004 |
P-values from Wilcoxon rank sum test were corrected for multiple testing (FDR) and differences in average beta values (Δβ) between the two groups are presented alongwith the details of methylation probes. Only differentially hypermethylated probes in patients with ECS passed the filtration criteria (Δβ >0.2 and FDR<0.05)