Table 1.
Functionalization of different resins with linker 1 and loading determination.
| chloro-functionalized PS resins |
amino-functionalized water-compatible resins |
||||||
| Merrifield 16 |
Jandajel 17 |
Tentagel 18 |
Hypogel200 19 |
Hypogel400 20 |
NovaPEG 21 |
Synbeads 22 |
|
| initial loading [mmol/g] | 0.74 | 1.00 | 0.30 | 0.92 | 0.71 | 0.66 | 0.70 |
| 23 | 24 | 25 | 26 | 27 | 28 | 29 | |
| linker loading [mmol/g] | 0.14 | 0.61 | 0.22 | 0.44 | 0.40 | 0.29 | 0.25 |
| coupling efficiency | 19% | 61% | 73% | 48% | 56% | 44% | 36% |
| 30 | 31 | 32 | 33 | ||||
| linker loading via insert [mmol/g] | – | – | 0.13 | 0.23 | 0.21 | – | 0.05 |
| coupling efficiency | – | – | 43% | 25% | 30% | – | 7% |