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. 2013 Feb 3;19:254–266.

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Copyright © 2013 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ephrin-A5 expression is observed in several parts of the developing eye. A and E: EphA5-AP staining is observed in the lens epithelium (le), lens bow (lb), cornea (c), and ciliary body (cb) in the E14 wild-type eye while absent in the ephrin-A5^-/- animal. B and F: Expression of ephrin-A ligands are maintained in the wild-type at P0 though in lower levels in comparison with earlier embryonic stages, while remaining absent in the ephrin-A5^-/- eye. C and G: Ephrin-A ligand expression is observed in the lens bow region of P7 wild-type mice while absent in ephrin-A5^-/- mice at the same age. D and H: High levels of ephrin-A ligand is observed in the cornea of wild-type mice at P7 and not present in ephrin-A5^-/- mice at the same age. Scale bars are in micrometers.