Table 1.
General characteristics of the study population
| General population (n=101) | GnRH agonist protocol (n=60) | GnRH antagonist protocol (n=41) | P | |
|---|---|---|---|---|
|
Age (years) |
34.1±5.1 (21–39) |
34.1±5.4 (21–39) |
34.1±4.7 (26–39) |
ns |
|
AMH (ng/ml) |
1.8±1.8(0.01-9.6) |
1.5±1.3 (0.01-8.2) |
2.3±2.2 (0.01-9.6) |
ns |
|
AFC (n) (2–9 mm) |
12.5±6.2 (2–34) |
11.8±5.3 (2–34) |
13.6±7.1 (4–28) |
ns |
|
ORPI |
1.0±1.5(0–8.8) |
0.7±1.2(0–8.8) |
1.3±1.8(0–7.6) |
ns |
|
BMI |
24.6±4.1 |
24.0±4.1 |
25.6±3.8 |
ns |
|
Tobacco use |
4% (4/101) |
3.3% (2/60) |
4.9% (2/41) |
ns |
|
Regular alcohol use |
1% (1/101) |
1.7% (1/60) |
0/41 |
ns |
|
Time of infertility (years) |
4.9±3.3 |
5.1±3.6 |
4.1±2.7 |
ns |
|
Aetiology (%) |
|
|
|
ns |
|
-Male |
35.6% (36/101) |
41.6% (25/60) |
26.8% (11/41) |
|
|
-Idiopathic |
25.7% (26/101) |
20% (12/60) |
34.1% (14/41) |
|
|
-Tuboperitoneal |
17.8% (18/101) |
16.7% (10/60) |
19.5% (8/41) |
|
|
-Endometriosis |
12.9% (13/101) |
15% (9/60) |
9.8% (4/41) |
|
|
-Tuboperitoneal+endometriosis |
4% (4/101) |
3.3% (2/60) |
4.9% (2/41) |
|
|
-Male+endometriosis |
3% (3/101) |
1.7% (1/60) |
4.9% (2/41) |
|
|
-Male+tuboperitoneal |
1% (1/101) |
1.7% (1/60) |
0.0% (0/41) |
|
|
Infertility |
|
|
|
ns |
|
-Primary |
78.2% (79/101) |
81.7% (49/60) |
73.2% (30/41) |
|
|
-Secondary |
21.8% (22/101) |
18.3% (11/60) |
26.8% (11/41) |
|
|
Total dose FSH (UI) |
1956±804 |
2136±774 |
1692±782 |
ns |
|
Total dose LH (UI) |
982±351 |
1035±322 |
903±380 |
ns |
|
Time of stimulation (days) |
10.2±2.1 |
10.6±2.1 |
9.5±1.9 |
ns |
|
Follicles (n) (hCG day) |
|
|
|
|
|
-≥10 mm |
12.8±8.6 |
12.8±7.3 |
12.8±10.4 |
ns |
|
-≥16 mm |
5.7±3.5 |
6.2±3.4 |
4.9±3.5 |
ns |
|
-≥18 mm |
3.8±2.6 |
4.2±2.2 |
3.3±2.9 |
ns |
|
Retrieved oocytes |
|
|
|
|
|
-Total |
9.7±7.1 |
9.7±6.0 |
9.6±8.4 |
ns |
|
-Metaphase II stage |
6.9±5.2 |
7.1±4.6 |
6.6±6.0 |
ns |
|
-Metaphase I stage |
1.3±1.8 |
1.2±1.6 |
1.5±2.1 |
ns |
|
-Germinal vesicle stage |
0.8±1.1 |
0.8±1.2 |
0.7±1.0 |
ns |
| Clinical pregnancy rate | 32.7% (33/101) | 31.2% (19/60) | 34.1% (14/41) | ns |
AMH: anti-Müllerian hormone ORPI: ovarian response prediction index.
AFC: antral follicle count BMI: body mass index.
ns: not significant.