Table 1.
In vitro anti-malarial activity of semi-synthetic artemisinins, synthetic OZ277 and thapsigargin against Plasmodium falciparum K1 and NF54 strains
|
Compounds |
Inhibitory concentrations (ng/ml) |
|||
|---|---|---|---|---|
| |
+P. falciparum K1 |
+P. falciparum NF54 |
||
| |
(Mean ± SE) |
(Mean ± SE) |
||
| IC50 | IC90 | IC50 | IC90 | |
| Artesunate |
0.60 ± 0.18 |
1.8 ± 0.1 |
0.98 ± 0.48 |
1.9 ± 1.1 |
| Artemether |
0.45 ± 0.28 |
0.80 ± 0.34 |
0.49 ± 0.18 |
0.98 ± 0.27 |
| OZ277 |
0.17 ± 0.03 |
0.42 ± 0.11 |
0.82 ± 0.09 |
1.6 ± 0.4 |
| Thapsigargin | 1612 ± 140 | 6850 ± 730 | 1940 ± 433 | 7455 ± 2307 |
+Data was obtained from three independent experiments. SE = standard error.