Table 4.
Clinical characteristics, laboratory results, radiologic findings and disease extent among patients with tuberculosis (TB)
| Survivors n=79 | Non-survivors n=21 | p value | |
|---|---|---|---|
| Age (years) |
68.2 [16.9] |
78.3 [9.6] |
0.010 |
| Male sex |
48 (61%) |
14 (67%) |
0.620 |
| History of TB |
6 (8%) |
4 (19%) |
0.120 |
| Co-morbidity |
27 (34%) |
12 (57%) |
0.055 |
| Diabetes mellitus |
24 (30%) |
6 (29%) |
0.872 |
| Malignancy |
6 (8%) |
9 (43%) |
<0.001 |
| Liver cirrhosis |
0 |
2 (10%) |
0.006 |
| Diagnosis evidence |
|
|
0.051 |
| Culture positive |
79 (100%) |
20 (95%) |
|
| Pathology positive |
0 |
1 (5%) |
|
| Mtb resistance |
|
|
|
| INH resistance |
8 (10%) |
0 |
0.128 |
| RIF resistance |
0 |
1 (5%) |
0.051 |
| Sputum AFS-positive |
52 (66%) |
11 (52%) |
0.257 |
| Radiographic pattern |
|
|
|
| Upper lung lesion |
53 (67%) |
13 (62%) |
0.656 |
| Cavitation |
11 (14%) |
1 (5%) |
0.251 |
| Disease extent |
|
|
0.653 |
| Pulmonary |
64 (81%) |
18 (86%) |
|
| Extra-pulmonary only |
3 (4%) |
0 |
|
| Mixed |
12 (15%) |
3 (14%) |
|
| Blood tests |
|
|
|
| Leukocyte, (/μL) |
9609 [4880] |
10297 [4207] |
0.542 |
| Interleukin-6 |
54.9 [257.3] |
98.2 [196.6] |
0.408 |
| Interleukin-10 |
5.6 [23.1] |
4.7 [12.2] |
0.814 |
| Interferon-gamma |
66.3 [472.7] |
15.4 [38.9] |
0.347 |
| TNF-alpha |
50.8 [375.5] |
32.7 [123.7] |
0.720 |
| MCP-1 |
25.0 [50.1] |
68.2 [116.1] |
0.012 |
| MIP-1alpha |
6.1 [29.8] |
1.8 [2.6] |
0.210 |
| MIP-1beta |
245.4 [1274.7] |
193.3 [366.2] |
0.752 |
| Decoy receptor 3 |
3.6 [3.8] |
5.3 [3.7] |
0.078 |
| Lipoxin |
1.7 [1.5] |
1.7 [1.2] |
0.939 |
| Prostaglandin E2 | 2.9 [8.1] | 3.4 [7.0] | 0.793 |
Data are no. (%) or mean [standard deviation].
Abbreviations: MCP, monocyte chemotactic protein; MIP, macrophage inflammatory protein; TNF, tumor necrosis factor.