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. Author manuscript; available in PMC: 2014 Jan 15.
Published in final edited form as: Cancer Res. 2013 Jan 15;73(2):662–671. doi: 10.1158/0008-5472.CAN-12-0653

Figure 7. Proposed model for Twist1-induced angiogenesis through CCL2 induction and macrophage recruitment.

Figure 7

Carcinoma cells expressing Twist1 upregulate CCL2 transcript leading to increased CCL2 protein in the tumor microenvironment. The CCL2 gradient attracts macrophages, which then promote angiogenesis.