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. 2013 Feb 7;7(2):e1996. doi: 10.1371/journal.pntd.0001996

Figure 4. Distribution of collagen isotypes in cardiac tissue of guinea pig infected with T. cruzi.

Figure 4

Deposition of collagen I (A), collagen III (B) and collagen IV (C) during the course of infection. Moderate increase of interstitial collagen I, at 365 dpi, 400× (D). Increase of perivascular collagen I, at 365 dpi, 400× (E). Severe increase of interstitial collagen III and moderate inflammation, at 365 dpi, 400× (F). Increase of collagen III near epicardial adipose tissue at 165 dpi, 400× (G). Detection of collagen IV in non-infected guinea pig (H). Increase of collagen IV in the basement of cardiac fibers, at 365 dpi, 400× (I). Acute phase (20–25 dpi): n = 12, late acute phase (40–55 dpi): n = 11, early chronic phase (115–165 dpi): n = 11 and chronic phase (365 dpi): n = 6.