Figure 6. Changes in the hydrogen bonds between residues Asp205 and Arg447 and residues Glu216 and Lys458 during the TMD simulation.

(A) Snapshots at 1 ps, 300 ps, 700 ps and 1000 ps. (B) Distances from the O^ε1 and O^ε2 atoms in Glu216 to the H^ζ1, H^ζ2 and H^ζ3 atoms in Lys458. (C) Distances from the O^δ1 and O^δ2 atoms in Asp205 to the H^η1 and H^η2 atoms in Arg447.