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. 2013 Feb 7;8(2):e56291. doi: 10.1371/journal.pone.0056291

Figure 5. Potential involvement of TAK1 in IL-8 secretion following H. pylori infection.

Figure 5

(A) Dose-dependent inhibition of IL-8 secretion, in the presence of the specific TAK1 inhibitor 5Z-7-Oxozeaenol (5–300 nM), following 4 hour infection of AGS cells with H. pylori P12ABCCC strain. (B) IL-8 secretion in the supernatants of AGS cells following 4 hour infection by the corresponding H. pylori CagA mutants, in the absence or presence of 70 nM 5Z-7-Oxozeaenol. (C) Expression of CagA, TAK1, IKBa phosphorylation at Ser32/36 and total IkBα determined by western blot, in total lysates of TAK1-/- mouse embryonic fibroblasts (MEFs) and respective control MEFs infected with H. pylori mutant strains for 4 hours. Un: uninfected MEFs.