Table 5. Altered expression of genes within PI3K pathway (AKT2, AKT2, PTEN, PIK3CA) and AKT activation (pAKT) in OC.
| Alteration | pAKT negative(N = 20) | pAKT positive(N = 73) |
| AKT1a | 1 | 1 |
| AKT2b | 0 | 0 |
| PIK3CAc | 8 | 23 |
| PTENd | 0 | 4 |
| AKT1, PTEN | 0 | 1 |
| AKT2, PTEN | 0 | 0 |
| PIK3CA, PTEN | 0 | 14 |
| AKT1, AKT2 | 0 | 2 |
| PIK3CA, AKT1 | 0 | 6 |
| PIK3CA, AKT2 | 0 | 5 |
| AKT1, AKT2, PTEN | 0 | 0 |
| AKT1, PIK3CA, PTEN | 0 | 3 |
| AKT2, PIK3CA, PTEN | 0 | 0 |
| AKT1, AKT2, PIK3CA | 0 | 4 |
| AKT1, AKT2, PIK3CA, PTEN | 0 | 0 |
a
High AKT1 expression as defined in the manuscript.
b
High AKT2 expression as defined in the manuscript.
c
High PIK3CA expression as defined in the manuscript.
d
PTEN loss as defined in the manuscript.