Table 2. Association of baseline levels of t-PA antigen, D-dimer and VWF with coronary heart disease in the Reykjavik Study (1925 cases, 3616 controls).
| Adjustment | Odds ratios for coronary heart disease (95% CI) per 1 SD higher level | ||
| t-PA antigen | D-dimer | VWF | |
| Adjusted for age, sex and period of recruitment | 1.25 (1.18, 1.33) | 1.01 (0.95, 1.07) | 1.11 (1.05, 1.18) |
| + non-lipid risk factors* | 1.14 (1.07, 1.22) | 1.04 (0.98, 1.10) | 1.08 (1.02, 1.15) |
| + lipid risk factors† | 1.07 (0.99, 1.14) | 1.06 (1.00, 1.13) | 1.08 (1.02, 1.15) |
Smoking status, body mass index, systolic blood pressure and any history of diabetes mellitus at baseline.
Total cholesterol and loge triglycerides.
When analyses were restricted to participants with complete information on C-reactive protein (1906 cases, 3573 controls), the odds ratios (95% CI) per 1 SD higher value of t-PA antigen were 1.26 (1.18, 1.33) when adjusting for age, sex and period of recruitment, 1.15 (1.07, 1.22) when additionally adjusting for non-lipid risk factors, 1.07 (0.99, 1.14) when additionally adjusting for lipid risk factors and 1.04 (0.97, 1.11) when additionally adjusting for C-reactive protein. Corresponding odds ratios were 1.01 (0.95, 1.07), 1.04 (0.98, 1.11), 1.07 (1.00, 1.14) and 1.05 (0.99, 1.12) for D-dimer and 1.12 (1.05, 1.18), 1.09 (1.02, 1.15), 1.09 (1.03, 1.16) and 1.06 (1.00, 1.13) for VWF.