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. 2013 Feb 7;8(2):e55420. doi: 10.1371/journal.pone.0055420

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© 2013 Tain et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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STZ induced an increase of ADMA level, and decreases of arginine-to-ADMA ratio and NO, consequently leading to low nephron number, kidney injury, and hypertension; maternal citrulline therapy decreased ADMA, increased arginine-to-ADMA ratio and NO, and increased DDAH activity in the STZ group to reduce kidney injury and hypertension. Dashed lines indicate the effects of maternal citrulline supplementation on STZ offspring.