Table 2. Plasma and renal levels of arginine, citrulline, and dimethylarginine in the offspring of STZ-induced diabetic mothers at 12 weeks of age.

	Control	STZ	Cit	STZ+Cit
	n = 6	n = 6	n = 6	N = 6
Plasma (µM)
Arginine	90.9±2.6	96.7±3.5	89±3.7	100.8±4.2
Citrulline	66.2±2.6	75.3±7	74.3±3.3	96.2±4.2a
ADMA	0.72±0.06	0.78±0.08	1±0.18	1.16±0.17
SDMA	0.51±0.1	0.86±0.11	0.81±0.26	1.33±0.32
Arginine-to-ADMA ratio	129.9±9.5	129±11.5	101.9±15.6	95.6±13.4
Kidney (µM/mg protein)
Arginine	29.6±3.9	54.5±2.7a	28.9±1.9b	40.9±2.2c
Citrulline	24.4±3.6	37.6±2.7a	34.6±4.2	34.1±2.3
ADMA	0.19±0.03	1.29±0.23a	0.29±0.12b	0.29±0.07b
SDMA	0.35±0.03	0.66±0.07a	0.52±0.26	0.37±0.05
Arginine-to-ADMA ratio	178.8±32.3	47.3±6a	165.9±35.1	231.8±86.9b

STZ, offspring of STZ-induced diabetic mother; Cit, offspring of control mother treated with 0.25% l-citrulline; STZ+Cit, offspring of STZ-induced diabetic mother treated with 0.25% l-citrulline.

^ap<0.05 vs. control;

^bp<0.05 vs. STZ;

^cp<0.05 vs. Cit.