Table 2. Plasma and renal levels of arginine, citrulline, and dimethylarginine in the offspring of STZ-induced diabetic mothers at 12 weeks of age.
Control | STZ | Cit | STZ+Cit | |
n = 6 | n = 6 | n = 6 | N = 6 | |
Plasma (µM) | ||||
Arginine | 90.9±2.6 | 96.7±3.5 | 89±3.7 | 100.8±4.2 |
Citrulline | 66.2±2.6 | 75.3±7 | 74.3±3.3 | 96.2±4.2a |
ADMA | 0.72±0.06 | 0.78±0.08 | 1±0.18 | 1.16±0.17 |
SDMA | 0.51±0.1 | 0.86±0.11 | 0.81±0.26 | 1.33±0.32 |
Arginine-to-ADMA ratio | 129.9±9.5 | 129±11.5 | 101.9±15.6 | 95.6±13.4 |
Kidney (µM/mg protein) | ||||
Arginine | 29.6±3.9 | 54.5±2.7a | 28.9±1.9b | 40.9±2.2c |
Citrulline | 24.4±3.6 | 37.6±2.7a | 34.6±4.2 | 34.1±2.3 |
ADMA | 0.19±0.03 | 1.29±0.23a | 0.29±0.12b | 0.29±0.07b |
SDMA | 0.35±0.03 | 0.66±0.07a | 0.52±0.26 | 0.37±0.05 |
Arginine-to-ADMA ratio | 178.8±32.3 | 47.3±6a | 165.9±35.1 | 231.8±86.9b |
STZ, offspring of STZ-induced diabetic mother; Cit, offspring of control mother treated with 0.25% l-citrulline; STZ+Cit, offspring of STZ-induced diabetic mother treated with 0.25% l-citrulline.
p<0.05 vs. control;
p<0.05 vs. STZ;
p<0.05 vs. Cit.