Figure 1. Schematic overview of experimental study design.

Wild-type FVB mice were exposed from two weeks prior to conception to 6 weeks of age to a low-fat (5%) regular mouse diet, or to high-fat (24%) diets based on either corn oil or flaxseed oil. At 6 weeks of age, all mice were shifted to the regular low-fat diet until terminal sacrifice at 10 weeks of age.