Figure 2. Body weight trajectories in F1 female mice, perinatally exposed to a low-fat (5%) regular mouse diet (indicated in black), or to high-fat (24%) diets based on either corn oil (red) or flaxseed oil (blue). Graph plots mean (and 95% confidence intervals) body weights of F1 female pups with age.

The increased body weights of mice fed high-fat diets were significant versus regular diet at 3 weeks of age and beyond (P<0.001; nonlinear repeated measures model); however, mice fed the high-fat corn oil diet shifted to the regular trajectory between 6 and 10 weeks of age. The slight dip in the growth curves at 3 weeks of age in all three groups is accounted for by the removal of male pups, which are slightly heavier than females.