Table 5. GSEA pathways down-regulated due to treatment with FO diet, as compared to control samples.
Pathway | NominalP-value* | FDRq value | Pathway (continued) | NominalP-value | FDRq value |
Organelle inner membrane | 0.0000 | 0.0185 | Cellular lipid catabolic process | 0.0088 | 0.0519 |
Microbody | 0.0000 | 0.0179 | Mitochondrial membrane | 0.0100 | 0.0163 |
Peroxisome | 0.0000 | 0.0161 | Cofactor metabolic process | 0.0101 | 0.0600 |
Transferase activity – transferring acyl groups | 0.0000 | 0.0172 | Hsa00620: Pyruvate metabolism | 0.0105 | 0.0581 |
Transferase activity – transferring groups other thanamino acyl groups | 0.0000 | 0.0214 | Detection of stimulus involved in sensory perception | 0.0122 | 0.0668 |
Mitochondrial envelope | 0.0020 | 0.0142 | Oxidoreductase activity | 0.0123 | 0.0616 |
Mitochondrion | 0.0021 | 0.0132 | Energy derivation by oxidation of organic compounds | 0.0125 | 0.0533 |
Hsa00020: Citrate cycle | 0.0021 | 0.0433 | Hsa00071: Fatty acid metabolism | 0.0126 | 0.0468 |
Electron carrier activity | 0.0040 | 0.0173 | Lipid catabolic process | 0.0128 | 0.0592 |
Coenzyme metabolic process | 0.0041 | 0.0508 | Mitochondrial respiratory chain | 0.0166 | 0.0221 |
Mitochondrial inner membrane | 0.0041 | 0.0182 | Aerobic respiration | 0.0189 | 0.0585 |
Cellular respiration | 0.0042 | 0.0435 | Hsa00030: Pentose phosphate pathway | 0.0199 | 0.0725 |
Envelope | 0.0058 | 0.0584 | Mitochondrion organization and biogenesis | 0.0218 | 0.0795 |
Organelle envelope | 0.0058 | 0.0563 | Mitochondrial lumen | 0.0219 | 0.0469 |
Mitochondrial part | 0.0059 | 0.0175 | Mitochondrial matrix | 0.0219 | 0.0445 |
Mitochondrial membrane part | 0.0060 | 0.0117 | Nucleobase – nucleoside and nucleotide metabolic process | 0.0246 | 0.0811 |
Generation of precursor metabolites and energy | 0.0060 | 0.0559 | Cofactor biosynthetic process | 0.0288 | 0.0932 |
Hsa00190: Oxidative phosphorylation | 0.0061 | 0.0214 | Oxidoreductase activity – acting on CH-OH group of donors | 0.0288 | 0.0734 |
Fatty acid metabolic process | 0.0064 | 0.0378 | Hsa00650: Butanoate metabolism | 0.0295 | 0.0919 |
Hsa00640: Propanoate metabolism | 0.0084 | 0.0499 | Hsa00280: Valine, leucine, and isoleucine degradation | 0.0343 | 0.0602 |
P<0.05;
FDR q<0.1.