Table 2. Seven functional classes of proteins we studied are found to be not significantly distinguished in their folded topology.

Functional class	Size of class	Subgroups, if any, included	One-tail p-value
Kinase	213	-	0.1449
Globin	32	Myoglobin and hemoglobin	0.4154
Dehydrogenase	297	-	0.3461
Polymerase	67	DNA/RNA polymerase	0.0572
Chaperone	33	-	0.2925
Antigen	49	-	0.4411
Muscle	18	Actin, myosin, titin, nebulin	0.1972

The shared folds between each functional class of proteins and their complement are not significantly small compared to what happens with random chances, with a one-tailed p-value greater than 0.05 in every case, suggesting that these cellular proteins are highly connected in structural fold space.