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. 2013 Feb 7;9(2):e1003276. doi: 10.1371/journal.pgen.1003276

Figure 8. Model for meiotic recombination in C. elegans.

Figure 8

In wild-type germlines, MRE-11 may create substrates at meiotic DSBs that allow COM-1 to efficiently remove Ku (and SPO-11). When COM-1 function is perturbed, MRE-11 mediated processing may still release SPO-11 bound oligos. However, MRE-11 activity alone is not sufficient to counteract Ku binding and prevent toxic NHEJ activity. Without COM-1 and Ku, SPO-11 is removed and EXO-1 promotes DNA end resection and allows the obligate COs to be formed. See text for further details.