Figure 1. Nucleotide and amino acid sequences of the V_H and V_L of three HuMAbs 5A7 (A), 3A2 (B) and 10C4 (C).

Closest germline sequences in NCBI database by IgBlast softwares were aligned. Complementarity-determining regions (CDRs) are indicated in red, blue and pink (CDRs 1, 2 and 3, respectively). V-D and D-J junctions in VH and V-J junctions in VL are shown in white, light gray and dark gray colors, respectively.