Table 3.
Estimated effects of 1998 legislation on paracetamol related registrations for liver transplantation and liver transplants by people aged 10 years and over in England and Wales, 1995-2009. Data are mean estimated no of registrations per quarter year, unless stated otherwise
| Estimate of absolute effect (October 1998 to 2009)* | Conservative† estimate of absolute effect (October 1998 to 2009)* | ||||||
|---|---|---|---|---|---|---|---|
| Without legislation‡ | With legislation‡ | Difference (95% CI)§ | Without legislation‡ | With legislation‡ | Difference (95% CI)§ | ||
| Paracetamol related registrations | |||||||
| Registrations | 18 | 7 | −11 (−20 to −1) | 11 | 7 | −4 (−14 to 5) | |
| Transplants | 8 | 5 | −3 (−12 to 6) | 7 | 5 | −2 (−11 to 7) | |
| All liver transplants | 132 | 149 | 17 (−30 to 63) | 139 | 149 | 10 (−37 to 57) | |
*Using interrupted time series segmented regression analysis,28 where the intervention point is taken as third quarter of 1998.
†Assuming flat trend in post-legislation period had the legislation not occurred.
‡Estimated for the mid-point quarter of October 1998 to 2009.
§Absolute difference of estimated number with legislation and estimated number without, taken at the mid-point of the post-intervention period. Confidence intervals taken from Stata results or calculated according to reference 37.