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. Author manuscript; available in PMC: 2014 Jan 28.
Published in final edited form as: Neurobiol Dis. 2012 Jul 28;0:200–210. doi: 10.1016/j.nbd.2012.07.019

Figure 5. Induction of β-galactosidase expression in the cerebellum by Cre recombinase.

Figure 5

(A) Purkinje cell-specific staining was observed in totteringPC-loss (Cacna1atg/flox mice carrying the Purkinje cell specific L7-Cre transgene) that also carried the Rosa26 Cre reporter allele. There was no obvious Purkinje cell loss in these mice. (B) No staining was observed in Cacna1atg/flox mice carrying the Rosa26 Cre reporter allele but not the L7-Cre transgene. (C) Cacna1atg/flox mice carrying the Rosa26 Cre reporter allele treated with intracerebellar injections of Cre-lentivirus revealed induction of β-galactosidase expression near the injection site. (D) Staining was absent in sections distant from the Cre-lentivirus injection site. Scale bar = 100 μm.