Table 3.
Association between the Common Genetic Risk Factors Identified and VT in the Chinese Population
| Genotype |
Cases |
Controls |
Risk of VT |
PAR | |
|---|---|---|---|---|---|
| n = 1,304 | n = 1,334 | OR (95% CI) | p Value | ||
| PROC c.565C>T (p.Arg189Trp) | |||||
| C/C | 1,236 (94.79%) | 1,322 (99.10%) | 1 | - | - |
| C/T | 68 (5.21%) | 12 (0.90%) | 6.06 (3.26–11.25) | 1.03 × 10−10 | 4.67% |
| PROC c.574_576dup/del (p.Lys192del) | |||||
| dup/dup | 1,219 (93.48%) | 1,302 (97.60%) | 1 | - | - |
| dup/del + del/del | 85 (6.52%) | 32 (2.40%) | 2.84 (1.88–4.29) | 2.77 × 10−7 | 4.14% |
| THBD c.−151G>T | |||||
| G/G | 1,269 (97.32%) | 1,321 (99.03%) | 1 | - | - |
| G/T | 35 (2.68%) | 13 (0.97%) | 2.80 (1.48–5.32) | 1.02 × 10−3 | 1.48% |
Hardy-Weinberg equilibrium tests for PROC c.565C>T, PROC c.574_576dup/del, and THBD c.−151G>T are p = 0.869, 0.657, and 0.858, respectively. The following abbreviations are used: VT, venous thrombosis; OR, odds ratio; CI, confidence interval; and PAR, population-attributable risk.